The EDEM2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to EDEM2. This antibody recognizes Human antigen. The EDEM2 Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. Catalyzes the first mannose trimming step, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle.
Post-translational Modifications: Glycosylated.
Similarity: Belongs to the glycosyl hydrolase 47 family